Engineering and Application of Pluripotent Stem CellsBefinden Sie sich in Frankreich? Wir haben eine Seite speziell für unsere Nutzer in Frankreich. Nagy , Andras, Turksen , Kursad Eds. This volume captures the rapid developments in the field of induced pluripotent stem iPS cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases. Specifically, representative protocols on various disease models have been collected from labs around the world.
Metrology-data driven non-invasive QC and scheduling of automated human iPSC generation and expansion. Mai Feb Targeting hemoglobin expression in erythrocytes from sickle-cell disease patient-derived induced pluripotent stem cells. Bonn, Deutschland Purification of cardiomyocytes from iPS cells with a non-clonal strategy enables automated planar patch clamp analysis of long QT-syndrome 3.
Parallelization in Automated Stem Cell Culture. Induced pluripotent stem cell-based modeling of neurodegenerative diseases: J Mol Med Berl , 95 7: Epub, 7 Jun Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. J Chem Technol Biotechnol. Epigenetic and transcriptional alterations in human neural stem cells subjected to reprogramming and subsequent redifferentiation.
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Befinden Sie sich in Frankreich? Wir haben eine Seite speziell für unsere Nutzer in Frankreich. Clements , Mike, Roquemore , Liz Eds. This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design. Current Protocol, Future Potential.
Springer Professional. Back to the search result list. Table of Contents. Hint Swipe to navigate through the chapters of this book Close hint. Abstract Transplantation of bone marrow stem cells is a widely used option to treat leukemias and other diseases.
Self-Renewal and Differentiation Mechanisms in Tumor Stem Cell Homeostasis One of the crucial questions in tumor biology is the identity of the cell and cellular programme that drive tumor growth. Two models best describe the growth characteristics of tumors: The stochastic model postulates that each cell within the tumor has the same capacity to proliferate and thus sustain tumor growth. Tumor heterogeneity is explained by the existence of multiple genetic tumor subclones, due to cumulative acquisition of genetic alterations. Conversely, the hierarchy model assumes that only a small subpopultation of tumor cells has the capacity to initiate and drive tumor growth, the so called tumor stem cells.
Author information: Today, the search for therapeutic options to treat retinal degeneration often relies on an in-depth understanding of the underlying pathological events. Alternatively, it is conceivable to search, Stem Cells Models an undirected screening approach, for chemical compounds affecting disease outcome. For both approaches, there is an urgent need for in vitro and, ideally, in vivo disease models that adequately reflect the site of Rachael Ray Turkey Meatloaf. Currently available animal models possess limitations as they often develop only defined aspects of disease.
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Jungverdorben, J; Till, A; Brüstle, O: Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. In: J Mol Med ( Berl). In: ISSCR/CRTD International Meeting, Stem Cell Models of Neural Regeneration and Disease, Dresden, Deutschland, Feb Dorn, I; Klich, K;. neurosensory stem cell biology and regenerative therapy of the inner ear (for further hearing loss models and small molecule screens investigating toxicity.
Development and characterization of a bone marrow stem cell niche model. Thesis (PDF Available) · January with Reads. Thesis for: Doctoral. In this thesis, I report on the experiments of stem cell transplantation in mouse models for Huntington´s disease. The most common rodent model for HD is the.