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Ruta graveolens Extracts and Metabolites against Spodoptera frugiperda. The biological activity of Ruta graveolens leaf tissue extracts obtained with different solvents ethyl acetate, ethanol, and water and metabolites psoralen, 2- undecanone and rutin against Spodoptera frugiperda was evaluated. Additionally, psoralen metabolite showed a high mortality as cypermethrin. Metabolite quantification in extracts shows the presence of 2-undecanone We suggest that these concentrations of 2-undecanone and psoralen in R. The toxicological effect of Ruta graveolens extract in Siamese fighting fish: The effects of pharmacological waste on aquatic ecosystems are increasingly highlighted in ecotoxicology research.